Interestingly, several other genetic defects affecting the centrosome/primary cilium also feature dyslipidaemic IR, including Alström Syndrome (e.g. (25), caused by biallelic ALMS1 variants (26) and Osteodysplastic Primordial Dwarfism of Majewski Type 2 (27), caused by biallelic PCNT variants (28). The gene discussed is ALMS1; the disease is Alstrom syndrome.