Characterization studies showed that a greater number of monocyte-derived CD14+/CD81+ EV were present in the BAL of patients with sepsis-related ARDS compared to patients with sepsis without ARDS (Fig. 2A, medians 1.23 × 108/mL vs. 6.26 × 107/mL, P = 0.015). The gene discussed is CD81; the disease is acute respiratory distress syndrome.