Thus, while castration‐induced AR changes were associated with decreases in Tfam and PGC‐1α at the level of both protein and gene expression in animal models,11 we observed no association between hypogonadism and cellular bioenergetics during RET at either the transcriptional (Figure5) or translational levels (FigureS4). The gene discussed is TFAM; the disease is hypogonadism.