T suppression via a single GnRh analogue injection was well tolerated by the volunteers and demonstrated the negative impact of hypogonadism on muscle hypertrophic programming via blunting the normal responses of muscle molecular transducers, that is, anabolic signalling proteins (mTOR pathway), T processing enzymes (HSDs), pro‐myogenic gene expression, which result in an increase in the capacity for protein synthesis (e.g. RNA biogenesis), and consequently MPS. This evidence concerns the gene MTOR and hypogonadism.