Compared with P, activation of adenosine monophosphate‐activated protein kinase (AMPKαThr172) (Z: 2.1 ± 0.4, P > 0.99 vs. P: 7.1 ± 2.4 fold change, P = 0.001, ES = 0.68, Figure4F) and regulatory‐associated protein of mTOR (RaptorSer792) (Z: 0.8 ± 0.1, P > 0.99 vs. P:1.8 ± 0.4 fold change, P = 0.01, ES = 0.59, Figure4G) was attenuated with hypogonadism acutely after 6 weeks of RET. The gene discussed is MTOR; the disease is hypogonadism.