RET and hypogonadism: We also demonstrate that anabolic and myogenic‐related gene expression are blunted during chemically induced hypogonadism even during RET, that is, represented by blunted IGF‐1Ec and IGF‐1Ea expression, because IGF‐1Ea is purported to correlate with increased translation and promote myogenesis differentiation,52 while IGF‐1Ec expression is associated with transcriptional activity and also initiation of satellite cell proliferation.52