Innate immune pathways such as RIG‐1 or cGAS signaling are essential protective mechanisms against cancer.[40] Accumulating reports have showed that intracellular dsRNA could activate innate immune response and stimulate production of type I IFN to prevent tumorigenesis.[41, 42] A recent work reveals that circNDUFB2 activates anti‐tumor immunity to suppress lung cancer growth.[31] How circRNA regulates innate immunity in CRC is largely unknown. This evidence concerns the gene RIGI and neoplasm.