A recent report shows circRNA circNDUFB2 activates RIG‐1 signaling to inhibit lung cancer progression.[31] To further explore whether circREEP3 suppresses antitumor immunity in CRC, a murine CRC cell line MC38 with or without mouse circReep3 knockdown was subcutaneously injected into C57BL/6 mice. Here, RIGI is linked to lung cancer.