PROM1 and neoplasm: CRC stem cells are characterized by powerful potential of self‐renewal and differentiation.[25] These cells defined by CD133 expression play vital roles in tumor growth, metastasis, and recurrence.[25, 26] We noticed that circREEP3 expression was higher in CD133high CRC sample cells, in which CD133+ cells were higher than the average ratios of CD133+ cells in all samples (Figure 3A).