We isolated circREEP3‐high (circREEP3 expression levels were higher than the average levels) or circREEP3‐low (circREEP3 expression levels were lower than the average levels) expression CRC sample cells with qPCR and injected them into NSG (NOD/Scid/Il2rg) mice. The gene discussed is IL2RG; the disease is colorectal carcinoma.