The sex-specific post-vaccination cellular and molecular dynamics observed in this study suggest that the more “primed” baseline immune states in COVR-M could have helped establish the more robust IFN, plasmablast, and antibody responses on days 1, 7, and 28, respectively, following influenza vaccination, which is antigenically distinct from SARS-CoV-2. The gene discussed is IFNA1; the disease is influenza.