COVID-19 pathway enrichment analysis revealed significant changes (q < 0.01) in pathways for viral infection (regulation of viral genome replication and viral entry into host cell) and immune response (regulation of type 1 interferon response and regulation of tyrosine phosphorylation of Stat protein, Gene Ontology (GO) Regulation of toll-like receptor signaling pathway), and the enrichment varied as a function of the viral load (Figure 2A; Table S2). This evidence concerns the gene SOAT1 and viral infectious disease.