PICALM and Alzheimer disease: The relevance of Aβ-LRP1 trafficking in Alzheimer’s disease pathogenesis is accentuated by the identification of several endocytic-related genes that amplify the risk of late-onset Alzheimer’s disease, including PICALM, BIN1 and RIN3,30–32 and abnormalities in the vesicular endosomal system.33–39 Hence, dysfunctions in the endocytic pathways appear to contribute to Alzheimer’s disease pathology.