LRP1 and early-onset autosomal dominant Alzheimer disease: Aβ aggregates into different assemblies ranging from soluble oligomers to insoluble fibrils, and several studies have shown that oligomeric and fibrillar species of Aβ contribute differently to initiation, seeding and propagation of the Alzheimer’s disease pathology.59–61 As Aβ monomers assemble into oligomers and fibrils, the number of ligands that bind to LRP1 increases and with this the total avidity.