APOE and cardiovascular disorder: After stratifying by APOE ɛ4 status to examine interactions between sex and cardiovascular disease risk on tau in APOE ɛ4 carriers and non-carriers, we found a significant two-way interaction between sex and cardiovascular disease risk on tau in the entorhinal cortex (β = 0.05; 95% CI, 0.02–0.08; P = 0.001), inferior temporal cortex (β = 0.03; 95% CI, 0.01–0.05; P =0.009) and meta-region (β = 0.02; 95% CI, 0.01–0.04; P = 0.008) only among APOE ɛ4 carriers.