APOE and cardiovascular disorder: This finding is consistent with a recent study showing that higher vascular risk and APOE ɛ4 interactively predicted memory decline in women but not men.22 Our results extend prior evidence of a stronger APOE ɛ4 effect on tau pathology in women,24–27 and introduce the role of cardiovascular disease risk as a potential factor contributing to this female APOE ɛ4-related susceptibility to tauopathy.