In that study, patients with metastatic cancer had higher rates of PRT30 in case of lower performance status, liver metastases, brain metastases, bone metastases, pleural metastases (or effusion), leukocytosis, elevated C-reactive protein, more than one cancer diagnosis, progressive disease outside the intended radiotherapy region, pain management with opioids, and ongoing steroid medication. This evidence concerns the gene CRP and metastatic malignant neoplasm.