Therefore, the induction of HSP activity by CB2 [18,76], and the addition of HSP by the delivery of mesenchymal stem cell exosomes [77], in concert, along with the pleiotropic effects of CB1 and CB2 on the glutamatergic and other pathways, may synergistically renormalize physiology through a systems therapeutic approach, serving to better prevent and remediate neurodegenerative diseases. Here, CNR1 is linked to neurodegenerative disease.