The inducible knockout of mTOR in mouse airway epithelial cells and alveolar type II epithelial cells will exacerbate smoking-induced inflammation, autophagy, necrosis, and apoptosis, which will lead to airway inflammation and emphysema (Liu et al., 2021; Wu et al., 2021; Ye et al., 2021). The gene discussed is MTOR; the disease is pulmonary emphysema.