Luo et al. (2020) reported the role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke. GRB2 is one of the hub genes in our study and its binding to miR-378a-3p has been predicted, as illustrated in Figure 6D. As a result, ceRNA regulatory network of GRB2 may also play an important part in CSE induced pathogensis. In addition, the ceRNA networks of hub genes were predicted and constructed providing research clues for further exploration, as plotted in Figures 3E, 6D‒E. Here, MEG3 is linked to ischemic stroke.