By analyzing diverse public PCa datasets (SU2C [2019, 444 samples], SU2C [2015, 150 samples] and FHCRC [2016, 176 samples]), we observed that many OTU family members showed high genomic amplification in PCa, among which OTUD6A and OTUD6B displayed high amplification rates (15–20%) in all three datasets (Fig. 1a). Here, OTUD6A is linked to posterior cortical atrophy.