As a result, a total of 50 genes, including known Brg1 downstream target genes (SNAI2, IL6, CYP1B1 and RUNX2)38–41, were found to be differentially expressed (34 upregulated and 16 downregulated) by at least 2.0-fold (P < 0.05) upon depletion of either OTUD6A or Brg1 in prostate cancer cells (Fig. 6i and Supplementary Data 3). This evidence concerns the gene RUNX2 and Familial prostate cancer.