In non-small cell lung cancer (NSCLC) EML4-ALK is one of the more common fusion events, but there are other reported variants of ALK fusion proteins that do not involve the EML4 gene such as KIF5B-ALK, STRN-ALK, HIP1-ALK, VCL-ALK, NPM-ALK, and TGF-ALK2–5. The gene discussed is NPM1; the disease is non-small cell lung carcinoma.