In the case of IL23R and NOD2 genes, we showed that the significance of some SNPs located in those genes was higher when only CD cases were analysed that in all IBD cases; namely rs11209023 in IL23R and rs5743292 SNPs in NOD2. The significance of those SNPs in each location of CD (ileal or ileocolonic) was similar for IL23R; while in NOD2 some SNPs were more significant in ileocolonic CD than colonic CD, such us, for example rs5743292 (Supplementary Table S3). Here, NOD2 is linked to Cowden disease.