Among the genes located on those loci, we found AGT gene, a gene involved in the genetic risk of thromboembolic events in IBD25; in the prognosis of colorectal cancer26, a cancer whose risk is increased in CD27; and it has been proposed that AGT is an important regulator of apoptosis in the intestinal epithelial cells28. This evidence concerns the gene CD27 and inflammatory bowel disease 25.