Further validating the robustness of our gain-of-function approach, we found ADAP1 is expressed in primary CD4+ T cells but not detectable in acute myeloid leukemia cell lines (e.g., Jurkat, K562) (Fig. 1g and https://www.proteinatlas.org/ENSG00000105963-ADAP1/cell+line), potentially explaining why ADAP1 was a hit in the screen. Here, ADAP1 is linked to acute myeloid leukemia.