The fact that acute myeloid leukemia cells (e.g., Jurkat, K562) do not express detectable ADAP1 (Fig. 1g and The Human Protein Atlas https://www.proteinatlas.org/ENSG00000105963-ADAP1/cell+line) suggests a selective pressure for cell transformation. This evidence concerns the gene ADAP1 and acute myeloid leukemia.