Like in patients, AML cell lines differed considerably in their metabolic profiles, whereby HL60 cells were among the most glycolytic with high extracellular acidification rates (ECAR) and low oxygen consumption rates (OCR), while THP1 cells (MLL-AF9+) and FLT3-ITD-positive AML cells (MOLM13 and MV411) were predominantly OXPHOS-driven (Fig. 4a, b). The gene discussed is MLLT3; the disease is acute myeloid leukemia.