Similar to higher lactate efflux activity in glycolytic PDK1High HL60 and K562 cell lines, FLT3-wt AML primary CD34+ cells were notably higher in their glycolytic lactate secretion activity compared to FLT3-ITD AML cell lines and primary CD34+ cells and healthy CB and PBSC CD34+ counterparts (Fig. 4f, g). This evidence concerns the gene FLT3 and acute myeloid leukemia.