KMT2A and acute myeloid leukemia: Like in patients, AML cell lines differed considerably in their metabolic profiles, whereby HL60 cells were among the most glycolytic with high extracellular acidification rates (ECAR) and low oxygen consumption rates (OCR), while THP1 cells (MLL-AF9+) and FLT3-ITD-positive AML cells (MOLM13 and MV411) were predominantly OXPHOS-driven (Fig. 4a, b).