PDK1 and acute myeloid leukemia: Despite the notion that FLT3-ITDs AMLs were generally low in PDK1 expression and less sensitive to DAP treatment (Fig. 5c–e), AML#20 provided an exception in that p-PDH Ser293 as well as ECAR levels were relatively high in this FLT3-ITD+ AML (Fig. 5f, g), which nicely correlated with DAP sensitivity (Fig. 5c).