After studying the in vivo effects of DAP PDX models of a highly glycolytic cell line and primary AML samples (Fig. 5l, m) we wished to compare the effect of in vivo PDK1 inhibition in PDK1high (FLT-wt) and PDK1low (FLT3-ITD) AML cell lines. The gene discussed is FLT1; the disease is acute myeloid leukemia.