PDK1 and acute myeloid leukemia: As PDK1 protein expression was negatively correlated with intracellular glutamine levels in primary AML patients (Fig. 4l) and PDK1 mRNA levels were negatively correlated with glutamine levels in AML cell lines (n = 12) in the CCLE metabolome dataset (Supplementary Fig. 3f), we speculated that OXPHOS-driven cells would ensure a higher uptake of glutamine to use this as a carbon source to maintain Krebs cycle activity.