Activation of NRF2 results in beneficial effects similar to those obtained with dietary MR; NRF2 activators prevent HFD-induced obesity and adiposity46, increased energy expenditure, reduced blood glucose, insulin, and plasma lipid levels47, and reduce liver lipid accumulation in DIO and diabetic mice46,47. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.