CPS1 and metabolic dysfunction-associated steatohepatitis: CPS1 expression by RNA-seq was found to be diminished in both bland steatosis (0.81 fold; FDR: 0.156) and NASH-fibrosis (0.78 fold; FDR: 0.052) when compared to healthy controls, but only reached statistical significance in the latter (Supplementary Fig. 1A).