CPS1 and metabolic dysfunction-associated steatohepatitis: On the other hand, in the immunohistochemistry staining, CPS1 was also found to be downregulated in NASH-fibrosis patients versus bland steatosis (6.6 × 105 ± 7.7 × 105vs. 1.8 × 106 ± 2.2 × 105 stained pixels, p = 0.003) (Fig. 2A).