Regarding the gene expression, out of the five enzymes analysed, the two mitochondrial-located enzymes showed a significant downregulation in bland steatosis in comparison with healthy controls: CPS1 was 0.32 fold in steatosis [CI95% 0.02–0.63] vs. healthy controls (onefold, [CI95% 0.75–1.32]) (p = 0.0003), but not statistically significant in patients with NASH-fibrosis when compared to bland steatosis (p = ns) (Fig. 1A). The gene discussed is CPS1; the disease is steatosis.