In this study, we performed integrative RNA sequencing data analysis of monozygotic twin discordant for schizophrenia, a lncRNA RP5-998N21.4 overexpressing SK–N–SH cell line, and public postmortem brain datasets to identify the potential coexpressed target genes of RP5-998N21.4, and we then identified the mechanism by which RP5-998N21.4 underlies the development of schizophrenia by regulating IFIT2- and IFIT3-mediated antiviral immune response pathways. Here, IFIT2 is linked to schizophrenia.