TLR3 and astrocytoma (excluding glioblastoma): IFIT2 and IFIT3 are IFITs; IFIT3 (ISG60) is also involved in poly I:C-induced CXCL10 expression through the Toll-like receptor 3 (TLR3)/IFN-β/STAT1 axis in U373MG human astrocytoma cells9, suggesting that IFITs may play important roles in a variety of biological processes, including physiological innate immunity and pathological inflammation in the central nervous system.