Moreover, we demonstrated that RP5-998N21.4OE-induced coexpressed DEGs in SK–N–SH cell lines were significantly enriched in immune defense-related pathways; two antiviral response-related genes, IFIT2 and IFIT3, were significantly enriched in both RP5-998N21.4-coexpressed schizophrenia-associated DEGs and RP5-998N21.4OE-induced DEGs and were identified as potential targets of lncRNA RP5-998N21.4. This evidence concerns the gene IFIT2 and schizophrenia.