We then observed significant overlap (three overlapping genes (IFIT2, IFIT3, and ANXA3; OR = 77.4, P = 7.4e−5; Fig. 1d) between RP5-998N21.4OE-induced DEGs in SK-N-SH cells and RP5-998N21.4-coexpressed schizophrenia-associated DEGs in twin subjects. The gene discussed is ANXA3; the disease is schizophrenia.