Although GLUT1 is a key transcriptional target of MYC and HIF1α, recent studies have also shown regulation of GLUT1 translation by RBPs during adaptive responses to hypoxia50, and codon-specific translational reprogramming of glycolytic metabolism occurs in melanoma, in this case, mediated by translational regulation of HIF1α by uridine 34 (U34) tRNA enzymes44. Here, MYC is linked to melanoma.