CTLA4 and rheumatoid arthritis: In total, 33 D2T RA cases (TNFi 11, IL-6Ri 7, CTLA4-Ig 5, JAKi 10) and 73 b/tsDMARD-naïve cases (TNFi 34, IL-6Ri 17, CTLA4-Ig 15, and JAKi 7) stopped treatment due to SAEs over the course of a year, most of which were adverse reaction.