血管性血友病(von Willebrand disease, VWD)是最常见的遗传性出血性疾病。血管性血友病因子(von Willebrand Factor, VWF)基因突变引起血浆VWF数量减少或质量异常是VWD的主要致病机制[1]。. This evidence concerns the gene VWF and platelet-type von Willebrand disease.