Previous research in a similarly sized cohort of patients with paired primary and matched metastatic tumour samples, identified somatic copy number losses at 9p21 (CDKN2A) and 14q (L2HGDH, HIF1A) as critical molecular alterations towards the development of metastatic disease in patients with ccRCC [5]. The gene discussed is HIF1A; the disease is metastatic neoplasm.