Among these, disruption of the canonical SREBP regulators SCAP, MBTPS1, and MBTPS2 conferred resistance to SARS-CoV-2 infection, with a similar effect for infection with the ACE2-independent HCoV-OC43 and HCoV-229E but not the ACE2-dependent HCoV2-NL63 (S6C Fig). This evidence concerns the gene MBTPS1 and infection.