COPZ1 and infection: In the interacting bacteria, the tripartite condition also severely downregulated the copper resistance system multicopper oxidase (ABUW_RS16135; log2FC, -3.00) and abrogated infection-specific upregulation in the heavy-metal associated domain-containing protein CopZ (ABUW_RS13140) observed in the AB + THP-1-dMs group (S1–S3 Tables).