In this study, most of the patients suffered from clinical RP, high titer of antinuclear antibody (ANA), strongly positive expression of an anti-scl-70 antibody, and pathological skin fibrosis, along with perivascular inflammation, intimal hyperplasia, and vascular loss, while very few cases had pathologically occlusive vasculopathy such as obliteration of the lumen and microthrombi. This evidence concerns the gene BTG3 and retinitis pigmentosa 1.