One such study, for example, has shown that reducing tumor stiffness and collagen organization via inhibition of the collagen-crosslinking enzyme lysyl oxidase (LOX) increased T cell migration, tumor infiltration with CD8+ T cells, and antitumor activity of PD-1 blockade therapy in a model of murine pancreatic cancer (32). This evidence concerns the gene CD8A and familial pancreatic carcinoma.