TGFB1 and neoplasm: Due to the high expression of Tgfbr2 and LAIR-1 in MC38 tumor–infiltrating macrophages, we hypothesized that blockade of LAIR-1 signaling via NC410 could synergize with TGF-β inhibition mediated by bintrafusp alfa to remodel the myeloid cell composition of the TME.