Transcriptomic analysis of MC38 tumor immune-infiltrating cells revealed increased frequency of T and NK cell subsets in NC410 plus bintrafusp alfa–treated tumors, compared with all other groups, with an increase in CD8+ T cells (3.0-fold), NK cells (2.5-fold), NKT cells (2.9-fold), and Treg cells (2.6-fold) in the combination compared with the control group (Figure 3, A and B). Here, CD8A is linked to neoplasm.