CD4 and neoplasm: Immunohistochemical analysis verified a profound reduction in the number of tumor-infiltrating CD8+ T cells, but not CD4+ T cells, in Whsc1-depleted CT26 xenografts and in the polyps of Apcmin/+Whsc1IEC–/– mice compared with that seen in Whsc1-intact lesions (Supplemental Figure 3, C and D).