Cell lines with mutant TP53 showed higher IC50 with FD-895 and pladienolide B. In the past study by our group, we observed that in the case of CLL patients harboring 17pDEL/TP53 mutations harboring CLL patients, the splice modulators were able to induce in vitro cytotoxicity suggesting that the induction of cell death was TP53 independent. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.