Moreover, the role of Wnt signaling has been well established in CLL [34], and in our previous study, in the RNAseq data analysis, we found that both LRP5 and GSK-3β were found to have 3.44, and 5.1-fold IR, respectively in CLL-B cells treated with splice modulator compared with control CLL [30]. The gene discussed is LRP5; the disease is B-cell chronic lymphocytic leukemia.