BTK and B-cell chronic lymphocytic leukemia: Another example of combination approach where either Sudemycins C, D1, or D6 with BTK inhibitor (ibrutinib) inhibitor led to induction of cell death in CLL-B cells further suggests that synergistic effect can be achieved by combining the SPLMs with different inhibitors to induce cell death via modulation of signaling and apoptotic machinery associated pathways.