Western blot analysis of Bax and Bcl-2 levels in the hippocampus revealed that the Bcl2/Bax ratio in PD mice was markedly high, relative to control group (p = <0.001), while treatment of PD mice with PF, SP600125, and PF+SP600125 markedly increased Bcl2/Bax levels relative to untreated PD mice (p = <0.05, <0.05, and <0.01, respectively, Figure 6D-E). This evidence concerns the gene BCL2 and Parkinson disease.