AGTR1 and cardiac hypertrophy: Interestingly, while global ablation of the Ang II type 1A receptor is cardioprotective following acute MI (68), direct activation of AT1R in cardiomyocytes has only a minimal impact on cardiac hypertrophy (69), suggesting a more important role for this receptor in cardiac nonmyocytes; these data are corroborated by studies demonstrating a reduction in aortic fibrosis in mice lacking AT1R in fibroblasts (70).