SIRPG and neoplasm: When equal numbers of A549 cells (1 × 106) were inoculated into NDG mice reconstituted with or without PBMCs for tumorigenesis assays, targeting SIRPγ with LSB2.20 resulted in better efficacy in suppressing tumor growth in humanized NDG mice than in NDG mice without PBMC reconstitution (Supplemental Figure 16, E–G).