Overexpression of YAP rescued the defect in the expression of IL-1β and GM-CSF cytokines and CD47 expression in SIRPγ-knockdown cancer cells (Figure 6J), supporting the notion that SIRPγ acts through the Hippo/YAP pathway to regulate the expression of IL-1β, GM-CSF, and CD47. The gene discussed is SIRPG; the disease is cancer.