In accordance with this idea, we observed that SIRPγ overexpression promoted growth of human LUAD tumors in the xenograft model, while knockdown of YAP inhibited tumor growth and abrogated the tumor-promoting effect upon SIRPγ overexpression (Figure 8, A and C, and Supplemental Figure 9, A–C). The gene discussed is YAP1; the disease is neoplasm.