These data indicate that SIRPγ expression in CSLCs activates YAP signaling to elicit IL-1β and GM-CSF cytokine release that can induce CD47 expression to inhibit phagocytosis in the general tumor cell population, thereby supporting the notion that SIRPγhi cancer cells enable tumors to bypass an important aspect of innate immune surveillance. Here, SIRPG is linked to cancer.