NR1I2 and obesity due to melanocortin 4 receptor deficiency: As the main factors affecting 4βHC levels are obesity, sex, and exposure to PXR‐activating chemicals, and not the genetic factors, and because BP is affected by salt and alcohol intake, antihypertensives, obesity, and sex among others, it is not surprising that finding consistent associations between CYP3A genotypes and BP has proven difficult.