REN and obesity due to melanocortin 4 receptor deficiency: The mechanisms of obesity‐induced hypertension have been suggested to include renin‐angiotensin‐aldosterone system activation mediated by the mechanical compression of kidneys, and sympathetic nervous system activation instigated by hyperleptinemia, hyperinsulinemia and/or obstructive sleep apnea leading to impaired renal natriuresis and vasoconstriction.5, 45