Of particular note, TYRP1 frameshift mutations, predominately p.N353Vfs*31 (6/7 tumors), were exclusively from one cohort (Newell et al., 2020); this variant (rs387906562) has been described as a pathogenic germline variant in oculocutaneous albinism type III (Chiang et al., 2009), but was only observed as a somatic mutation in these samples. Here, TYRP1 is linked to oculocutaneous albinism type 3.