MAPK1 and cancer: Upon RTK activation, GAB2 interacts with receptors serving as a gateway for activation of the downstream signaling cascade, including RAS‐RAF‐MEK‐ERK, and RAC/JNK, STATs and AKT; amplification has been shown to directly influence proliferation, and cell cycle progression in breast (Bocanegra et al., 2010) and ovarian (Dunn et al., 2014) cancer.