Upon RTK activation, GAB2 interacts with receptors serving as a gateway for activation of the downstream signaling cascade, including RAS‐RAF‐MEK‐ERK, and RAC/JNK, STATs and AKT; amplification has been shown to directly influence proliferation, and cell cycle progression in breast (Bocanegra et al., 2010) and ovarian (Dunn et al., 2014) cancer. Here, AKT1 is linked to cancer.