PFS: progression-free survival; OS: overall survival; ORR: objective response rate; BRCA: breast cancer-associated; PDAC: pancreatic ductal adenocarcinoma; ATM: ataxia-telangiectasia mutated; PALB2: partner and localizer of BRCA2; FANCB: FA complementation group B; PTEN: phosphatase and tensin homolog; CCNE1: cyclin E1; SD: stable disease; PR: partial response; CR: complete response. The gene discussed is PALB2; the disease is breast carcinoma.