Responses to MTHFD2 inhibitors also corresponded to MTHFD2 protein levels in AML cell lines compared with less sensitive LCL cells, whereas the expression profile of MTHFD1, SHMT1 or SHMT2 in these cells did not predict MTHFD2 inhibitor sensitivity (Extended Data Fig. 4). The gene discussed is MTHFD1; the disease is acute myeloid leukemia.