Third, lipid metabolism-modifying SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily a, member 4 (SMARCA4) and Peroxisome Proliferator Activated Receptor Gamma (PPARG) exhibited increased activity in SOD1G93A astrocytes and in ALS patients vs. respective controls (Fig. 8c). The gene discussed is PPARG; the disease is amyotrophic lateral sclerosis.