As a future direction of research, we suggest functional follow-up studies to discover the roles of the IA-associated genes, in particular FMNL2 and TBC1D2 which are highly expressed in cerebral artery and intracranial aneurysm tissue, and to discover how the damaging variant in those genes contribute to IA pathophysiology. This evidence concerns the gene TBC1D2 and Dilatation of the cerebral artery.