Another modifiable factor is the tumour immune microenvironment, which can be converted from cold to hot using certain chemotherapeutic drugs—combined treatment of murine lung adenocarcinoma models using oxaliplatin and cyclophosphamide was found to be associated with an increased CD8+:regulatory T cell ratio within tumours, increased presence of tumour-antigen-specific TILs, increased TIL PD-1 expression, and increased PD-L1 expression by tumour stromal cells [81]. This evidence concerns the gene CD274 and lung adenocarcinoma.