Aberrant STAT3 activation has been observed in various cancer types, including lung, breast, colon, liver, pancreas, head and neck, kidney, and prostate cancers, as well as multiple myeloma and plays crucial roles in tumorigenesis by promoting cell proliferation, survival, invasion, metastasis, angiogenesis, and suppression of antitumor immunity33–37. The gene discussed is STAT3; the disease is AL amyloidosis.