NLRP3 and anaphylaxis: Remarkably, mice sensitized with Prup3_complex which lacked a functional NLRP3 pathway did not suffer from anaphylaxis after being challenged with Pru p 3, and their drop in body temperature was significantly milder even when compared to mice with functional NLRP3 that had been sensitized with only Pru p 3 (Fig. 3B).