The selected models (MC38, Hepa1-6, CT26 and EMT-6) are known to be sensitive (or partial) to anti-PD-1 treatment with a tumor growth inhibition (TGI) range of 30–70%, (Table 1) compared to other syngeneic models (Fig. 1A), thus implicating the presence of intrinsic anti-tumor immunity. This evidence concerns the gene PDCD1 and neoplasm.