CD4+ and TAM depletion on the other hand slightly enhanced the anti-PD-1 efficacy (TGI 81% and 75% respectively), while CD25+ depletion increased tumor efficacy (TGI 92%), suggesting that the Treg and TAM mediated immune suppressive TME countered the anti-PD-1 MOA. Here, PDCD1 is linked to neoplasm.