Consistent with the role of SIKs as critical effectors of LKB1-mediated tumor suppression in the lung, mouse lung tumors with CRISPR/Cas9-mediated targeting of Siks also had lower expression of several ATII markers, suggesting that the LKB1-SIK axis maintains ATII identity (Supplementary Fig. 11g)35,36. This evidence concerns the gene SIK1 and neoplasm.