We initiated tumors in KT;Lkb1XTR/XTR and KT;Lkb1XTR/XTR;FLPo-ERT2 mice with lentiviral Cre, began weekly treatment with either vehicle or tamoxifen upon detection of lung nodules (which ranged from 17 to 21 weeks after tumor initiation), and tracked tumor volume by μCT for 6–10 weeks (Fig. 2a and Supplementary Fig. 6a). Here, MAPK3 is linked to neoplasm.