Through the manipulation of LKB1 in lung adenocarcinoma cell lines in vitro and comparative analyses between LKB1 wild-type and mutant lung tumors, many consequences of LKB1 inactivation have been identified, including oxidative and ER stress, unique metabolic dependencies and therapeutic vulnerabilities, as well as an immunosuppressive microenvironment27–34. This evidence concerns the gene STK11 and lung adenocarcinoma.