After 6 weeks of Lkb1 restoration, tumor burden was significantly decreased, albeit to a lesser extent as compared to the Trp53 wild-type setting, including a twofold decrease in total lung weight and total tumor area, and a nearly fourfold reduction in average tumor size (Supplementary Fig. 5b–f, Fig. 1c–e, and Supplementary Fig. 3a, b). This evidence concerns the gene STK11 and neoplasm.