Given the critical role of the p53 tumor suppressor in lung adenocarcinoma, as well as the functional link between LKB1 and the pro-apoptotic and growth-suppressive functions of p53, we determined whether concomitant inactivation of Trp53 would abrogate the growth-suppressive effects of Lkb1 restoration45–49. Here, TP53 is linked to lung adenocarcinoma.