Consistently, Lkb1 restoration in lung cancer cell lines derived from tumors from KPT;Lkb1XTR/XTR;FLPo-ERT2 mice resulted in a significant decrease in the fraction of cells in S phase and variable effects on the rate of cell death after Lkb1 restoration (Supplementary Fig. 7d–g). This evidence concerns the gene MAPK3 and lung carcinoma.