VDAC3 KO male mice were infertile, consistent with a previous study32, and breeding of male dKO mice with female WT mice revealed that only 2 of the 35 plugged females gave birth to pups, with the number of pups per mother also being low, indicative of severe infertility in the dKO male mice (Fig. 5g). The gene discussed is VDAC3; the disease is Infertility.