Among PLWH who were naive to COVID-19 at study entry, we observed a weak positive correlation between recent CD4+ T-cell count and ACE2 displacement activity after one dose that was not statistically significant (Spearman’s ρ = 0.18, p = 0.09), but no association at either time point after two doses (Fig. 2e). Here, ACE2 is linked to COVID-19.