E2F1 and central nervous system cancer: We searched for transcription factors that are positively co-expressed with EIF4EBP1 in gliomas and found EIF4EBP1 mRNA expression to be significantly and positively associated with the mRNA expression levels of MYBL2, FOXM1, ETS1, HIF-1A, JUN, E2F1, and E2F6 in the REMBRANDT dataset [26] (Fig. 2A–G).