By functional knockdown experiments, we uncovered that ETS1 and MYBL2 regulate the transcription of endogenous EIF4EBP1 in glioblastoma cells, highlighting novel regulators of EIF4EBP1 transcription that complement the transcription factors previously reported, including MYC [15], the androgen receptor [16], ATF4 [15], ATF5 [17], and HIF-1A [18]. The gene discussed is ATF5; the disease is glioblastoma.