EGFR and glioblastoma: The initiation and progression of IDH-wildtype glioblastomas are driven by genetic alterations that inactivate tumor suppressor genes like PTEN, CDKN2A, RB1, NF1, and TP53, or activate cellular oncogenes like EGFR, PDGFRA, CDK4, MDM2, and PIK3CA [24].