MB and Cowden syndrome 1: Serum biochemical indicators showed that compared with the NC group, the concentration of creatine kinase (CK, 383.8 ± 192.2 U/L vs. 3651.0 ± 577.4 U/L, p < 0.0001) (Fig. 1a) and myoglobin (9.3 ± 1.0 ng/mL vs. 424.2 ± 52.8 ng/mL, p < 0.0001) (Fig. 1b) in the CS group was significantly up-regulated.