From the quantitative analysis results, it can be seen that the Ki67 proliferation signal of the RSPL group is only 10% of that of the PBS control group, which is 1/4 of that of the SCL group (Fig. 6f), which also strongly illustrates that TPDT can more fully inhibit the proliferation of tumor cells than nontargeted PDT. Here, MKI67 is linked to neoplasm.