PDCD1 and neoplasm: Notably, there was a significant reduced in tumor weight in the PLGA (PD-L1 siRNA+PD-1 siRNA)-NPs with vaccination group as compared with that in the positive control with vaccination (83% decrease, p<0.001) and anti-PD-L1+anti-PD-1 with vaccination groups (78% decrease, p<0.001) (figure 5C).