PLOD1 and Insulin resistance: Polycystic ovary syndrome (PCOS), a multisystem reproductive metabolic disease of the reproductive system, is characterized by the pathological accumulation of nonmaturating and atretic follicles, ovarian and stromal abnormal hyperplasia, hyperandrogenaemia (HA), hyperinsulinaemia, insulin resistance (IR), aberrant metabolism, an imbalance in the ratio of luteinizing hormone (LH) to follicle-stimulating hormone (FSH), and polycystic ovaries [1].